The heart is frequently affected by conditions that originate elsewhere in the body, leading to cardiovascular complications in other diseases. For instance, cancer treatments like chemotherapy can damage cardiac tissues, while chronic inflammatory diseases, such as rheumatoid arthritis, elevate the risk of heart attacks. These complications not only worsen a patient’s prognosis but also complicate treatment strategies. Managing cardiovascular risks in patients with systemic diseases demands a collaborative approach between cardiologists and other healthcare providers. From advanced diagnostic tools to innovative therapies, addressing cardiovascular complications in such cases ensures holistic care that reduces mortality and enhances overall well-being.