Conditions that affect the pericardium can cause a range of cardiovascular symptoms and complications. Pericardial diseases, such as acute pericarditis and chronic constrictive pericarditis, can disrupt the heart's ability to function properly by limiting its movement or causing fluid accumulation. When left untreated, these conditions can result in reduced cardiac output and complications such as cardiac tamponade, a life-threatening situation where fluid accumulation puts pressure on the heart. Effective management of pericardial diseases includes addressing the underlying cause, whether it be infection, autoimmune disorder, or trauma. Treatments can range from anti-inflammatory medications to surgical procedures for fluid drainage or pericardial resection, aimed at restoring normal heart function and alleviating symptoms.